ANYTIME. ANYWHERE. ANY FOOD.1*

The oral TPO-RA patients can take when and where they want, with any food they want, on a consistent schedule.1-3

resources

Start with one pill, once a day

Start with the lowest dose of Doptelet needed to achieve and maintain a platelet count of ≥50x109/L. Dose adjustments are based on platelet count response. Do not use Doptelet to normalize platelet counts.1†‡§

Recommended starting dose:

20 mg

ONE PILL, ONCE DAILY1†

Titrate with one dose strength1

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Titration Calculator

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2

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My patient is currently taking Doptelet at this dosage strength:

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20 mg
once a week
LEVEL 2
20 mg
twice a week
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40 mg
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20 mg
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20 mg
once a week
LEVEL 5
40 mg
3 times a week
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20 mg
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LEVEL 6
40 mg
once a week
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Recommended starting dose:
20 mg once daily.

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TPO-RA characteristics to considerII¶

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Product characteristics

Doptelet1*#Eltrombopag2**Romiplostim3††

Oral administration

++-

Bioavailability not impacted by food type

+-+
mg

Single dosage strength*

+--
dna

No dose restrictions based on population ancestry demographics

+-+
Dosing comparisons do not imply efficacy or safety.
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*Food is required when taking Doptelet.1 
†Start patients taking moderate or strong dual inhibitors of CYP2C9 and CYP3A4 with 20 mg 3 times a week; start patients taking moderate or strong dual inducers of CYP2C9 and CYP3A4 with 40 mg once daily. Please see full Prescribing Information for additional information on dose adjustments.1
‡After initiating therapy with Doptelet, assess platelet counts weekly until a stable platelet count of ≥50×109/L has been achieved, and then obtain platelet counts monthly thereafter. Obtain platelet counts weekly for at least 4 weeks following discontinuation of Doptelet.1
§After adjusting dosage, wait 2 weeks to assess the effects of this regimen and any subsequent dose adjustments.1
IIDosing comparisons do not imply comparable efficacy or safety.
Includes Promacta®, Alvaiz®, and generic bioequivalents.2,3
#Doptelet has demonstrated safety in patients of Asian descent without the need for special dosing; no dose adjustments necessary for different conditions and population demographics.1
**Eltrombopag must be taken at least 2 hours before or 4 hours after other medications, calcium-rich foods, or supplements containing polyvalent cations.2 
††Romiplostim requires office visits for treatment injections.3 

TPO-RA=thrombopoietin receptor agonist.

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  1. DOPTELET (avatrombopag) [prescribing information]. Morrisville, NC: AkaRx, Inc; 2025.
  2. Promacta (eltrombopag) [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2023.
  3. Nplate (romiplostim) [prescribing information]. Thousand Oaks, CA: Amgen; 2025.