ITP Dosing

For your adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment
 

 

ONE DOSAGE STRENGTH HELPS MAKE TITRATION MANAGEABLE FOR YOU AND YOUR PATIENTS1

Titrate up or down as necessary, based on platelet count (see dosing table below for titration criteria)

 

Chart: Doptelet dosing

 

After initiating therapy with DOPTELET, assess platelet counts weekly until a stable platelet count of ≥50x109/L has been achieved, and then obtain platelet counts monthly thereafter. Obtain platelet counts weekly for at least 4 weeks following discontinuation of DOPTELET.

 

TARGET THE RIGHT RESPONSE FOR YOUR PATIENT1

Initial dosing: Start with 1 tablet (20 mg) once daily with food, then dose-adjust if needed based on platelet count.

DOPTELET dosing table

PLATELET COUNT (×109/L) DOSE ADJUSTMENT OR ACTION
Less than 50 after at least
2 weeks of DOPTELET
  • Increase 1 Dose Level (see figure above)
  • Wait 2 weeks and assess the effects of this regimen and any subsequent dose adjustments
Between 200 and 400
  • Decrease 1 Dose Level (see figure above)
  • Wait 2 weeks and assess the effects of this regimen and any subsequent dose adjustments
Greater than 400
  • Stop DOPTELET
  • Increase platelet monitoring to twice weekly
  • When platelet count is <150×109/L, decrease 1 Dose Level (see figure above) and reinitiate therapy
Less than 50 after
4 weeks of DOPTELET
40 mg once daily
  • Discontinue DOPTELET
Greater than 400 after
2 weeks of DOPTELET
20 mg weekly
  • Discontinue DOPTELET

 

Doptelet Safety
DOPTELET Safety Profile

The safety profile is based on pooled data from 4 clinical studies.1

SEE THE DATA

 

Reference:

1. DOPTELET [package insert]. Durham, NC: Dova Pharmaceuticals, Inc; 2019.